Colorectal cancer is among the largest cancer burdens in the world today. Nearly 1.4 million people are diagnosed and almost half this number will die from the disease this year1. Although Japan represents the worlds highest incidence of the disease, Europe represents the highest risk for death from colorectal cancer2. In Europe, CRC is the third most common cancer and is one of the leading causes of cancer death, with 500,000 new cases and a quarter million deaths expected in 2018. And with aging demographics in the industrialized regions, the unmet medical need is expanding: death from CRC is expected to nearly double within the next 20 years3.
De Rosa et al. The biological complexity of colorectal cancer: insights into biomarkers for early detection and personalized care. Therap Adv Gastroenterol. 2016 Nov;9(6):861-886. Epub 2016 Aug 7.
Ferlay et al. GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. Lyon, France: International Agency for Research on Cancer, 2010: http: //globocan.iarc.fr/
Binefa et al. Colorectal cancer: From prevention to personalized medicine. World J Gastroenterol 2014 June 14; 20(22): 6786-6808